{"metadata":{"accession":"A0A8C7MS46","id":"A0A8C7MS46_ONCKI","source_organism":{"taxId":"8019","scientificName":"Oncorhynchus kisutch","fullName":"Oncorhynchus kisutch (Coho salmon)"},"name":"Phosphatidylinositol-binding clathrin assembly protein","description":["Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF)"],"length":670,"sequence":"MSGQSITDRITAAQHSVTGSAVAKTVCKATTHEIMGPKKKHLDYLIHCTNEMNVNIPQLADTLFERTASTSWVVVFKSLTATHHTMVYGNERFIQYMASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTIPIIQNQMDALLDFNVNANELTNGVINASFMLLFKDSIRLFAAYNEGIINLLEKYFDMKKTQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKVKDSTAASRASTLSNAVSSLANTGISFTKVDEREKQAALEEEQARLKALKEQRLKDLQKGPSFSATTAASPVSMDGGTINTAPAIDLFSTPSFANSTSKAASDLLDLQPVFQQQALPISTGLPTANTWGDPFTSTEAVDDSIPNFNPFLSHPVVDAVHLPVDSSDGVSSRTPSHEMFGDSFCGPASYPTTPLFQSEPPAVAGLFGGFSASPTPQPQTARGLNVDFDSVFGNNVDSAVASLPGQGQIPSGQQPGKLVSDDLDSSLANLVGNLGIGNGVAKNDIHWSQPGEKKLTGGNNWQPKTAPSTTWNPATMNGMHFPQYAPSVMAFPATTPTGMMAYGMPPQMGSMGMMTQPTIMYSQPVMRPANPFGTAPGAQQMQFM","proteome":"UP000694557","gene":"PICALM","go_terms":[{"identifier":"GO:0005543","name":"phospholipid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005545","name":"1-phosphatidylinositol binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0030276","name":"clathrin binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0048268","name":"clathrin coat assembly","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0030136","name":"clathrin-coated vesicle","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0072583","name":"clathrin-dependent endocytosis","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"9552d3e056c56f6fe46d99bc0a18241f3abe1baa","counters":{"domain_architectures":20686,"entries":14,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"profile":1,"smart":1,"ssf":2,"cdd":1,"pfam":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":20686}}}