{"metadata":{"accession":"A0A8C7IA19","id":"A0A8C7IA19_ONCKI","source_organism":{"taxId":"8019","scientificName":"Oncorhynchus kisutch","fullName":"Oncorhynchus kisutch (Coho salmon)"},"name":"ubiquitinyl hydrolase 1","description":["Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration"],"length":756,"sequence":"LCKVLVYWSCGAEPLPAAASPSVGATMTELGTKWACEYCTFENWPSAIKCTMCRAQRPSGGAIITEEPFRSSPGLDTSRQWEPPSLSNSPPKGGSSLLICPDSSARPRVRIADTPETPSSKWSCHICTYLNWPRAIRCTQCLCQRHRPTESPQTSGSGCRTAPPSTPTDPCEEYNDRNRLNTRAQHWTCAACTYANWPNACKCVVCDHPRPNSLTEPIELASEPESLPPSILNEQDRDNRRGGLGGGGGGGVVGCSGGQRRSPPTSKREAEVKMDFQRIELASGAGVGSIEEQQVDFKRLKQIKNRMRRTDWLFLNACAGVVEGDLAAVEAYKSSGGDIARQLTSDEVRLLNRSSAFDDGFTLVHLAIRFQRQDMLAVLLTEVSQQAAKCIPAMVCPELTEQIRREVAASLHQRKGDFTCYFLTDLVTFTLPADIEDLPPTVQEKLFDEVLDRDVQKELEEESPIINWSIELGTRLDSRLYALWNRTAGDCLLDSVLQATWGIYDKDSVLRKTLHDSLHDCSHWFYTRWKEWESWYSQSFGLHFSLREEQWQEDWAFILSLASQPGASLEQTHIFVLAHILRRPIIVYGVKYYKSFRGETLGYTRFQGVYLPLLWEQSFCWKSPIALGYTRGHFSALVAMENDGFDNRGAGANLNTDDDVTVTFLPLVDSERKLLHIHFLSAQEMGNEEQQEKLLREWLDCCVTEGGVLVAMQKSSRRRNHPLVTQMVEKWLDGYRQIRPCASLSDGEEEEEEEDE","proteome":"UP000694557","gene":"ZRANB1","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"fd31f7e1f86995f39b0b8f037100cf8df21a447f","counters":{"domain_architectures":199,"entries":18,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"profile":2,"cathgene3d":3,"ssf":1,"smart":1,"pfam":2,"cdd":1,"panther":1,"prosite":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":199}}}