{"metadata":{"accession":"A0A8C6S302","id":"A0A8C6S302_NANGA","source_organism":{"taxId":"1026970","scientificName":"Nannospalax galili","fullName":"Nannospalax galili (Northern Israeli blind subterranean mole rat)"},"name":"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein","description":["Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils"],"length":1643,"sequence":"MEAPDSSGDPGGDGTQPDARVPGSGQCVAARESERQLRLRLCVLNEILGTKRDYVGTLRFLQSAFLQRIRQNVADSVEKGLTEENVKILFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKVPAARAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGMLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDALIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMNRKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGINLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLTQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFKDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLIPPQEEDYGFELEEKNKAVVVKLVQRGSLAEMAGLQMGRKVYSINEDLVFLRPFSEVETILNQSFCSRRPLRLLVATKARETIKVPDHPEALSFQIRGAAPPCIFAVGRGSEAVTAGLCAGQCILKVNGNSVANDGALEVLEHFQAFRSRREEALGLYQWVYHSHEDAQQARASQGAPDEDPQEDDQPDSALPLLSLGPQLSLREDSAVVSLMVDNVHLEHGVVYEYVSTAGAKCHVLEKIVEPRGCFRLAAKILEAFAADDSIFVQNCGRLMAMSSAIVTMPHYEFRNICDTKLENIGQRIAHYQEFAVHLKNRVSPPFKQAPLEPHPLCGLDFCPTNCHVNLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQHCITTMAAPSWKCLPAADGDPQGQGLSDSSFGPASGTLSQQDRGLSFLLRQEDREIQDGYLQLFTKLDVALKEMKQYVTQINRLLSTITEPTSAAPCDPSLAEETSSSPLVSEESEADRTDHGGIKKVCFKVSEDEQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSIHTLLKGPVMSRAFEETRHFPMEHNWQEFKQKEECTVRGRSLIQISIQEDPWNLPSSIRTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAIFCQALVAAVCTFSEQLQAALSYRYNNNGEYEDSSRDASRKWLEQVAAIGALLHWQSLLAPASVKEEQIMLEDIWVALSELDSVTFSFKQLDENSVANTNIFYHIEGSRQALKVVFYLDSFHFSRLPSRLEGGASLRLHTVLFTKALEGVEGPPPGSQAVEELQQEINSQSLEKVQQYYRKLRAFYLERSNLPTDTNSTAVKIDQLIRPINALDELCRLMKSLVHPKPGTTGNLGAGLIPVSSELCYRLGACQITMCGTGMQRSTLSVSLEQAAILARSHGLLPKCVMQATDIMRKQGPRVEILAKNLRIKDPMPQGAPRLYRLCQPPVDGDL","proteome":"UP000694381","gene":"Prex1","go_terms":[{"identifier":"GO:0005085","name":"guanyl-nucleotide exchange factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0035556","name":"intracellular signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"acc90197b10e90cd7e7b8cdea4a3498807956ec7","counters":{"domain_architectures":1338,"entries":33,"isoforms":0,"proteomes":1,"sets":6,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"ssf":4,"profile":3,"cdd":3,"pfam":3,"smart":3,"panther":1,"prosite":1,"interpro":11},"proteome":1,"taxonomy":1,"similar_proteins":1338}}}