{"metadata":{"accession":"A0A8C6PA02","id":"A0A8C6PA02_NOTFU","source_organism":{"taxId":"105023","scientificName":"Nothobranchius furzeri","fullName":"Nothobranchius furzeri (Turquoise killifish)"},"name":"Voltage-dependent L-type calcium channel subunit beta-2","description":["Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current. Plays a role in shifting voltage dependencies of activation and inactivation of the channel. May modulate G protein inhibition. May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. Involved in membrane targeting of the alpha-1 subunit CACNA1C"],"length":623,"sequence":"MRVDTELSSTFAGTVTMLLSVSPQGSADSYTSRPSDSDVSLEEDKEAARREAERQAQTQLDKARTKAVAFAVRTNVSYSPSNDDDVPVPGMAVSFEAKDFLHVKEKFNNDWWIGRLVKEGCDIGFIPSPVKLENTRILQEQRAKQGKFYSSKLGANSSSSLGEVVSNSRKSTPPSSAVDIDATGLDAEDSELQVNLRSPKASPNTVLSPLAKEKRMPFFKKMEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSNLAEVQSEIERIFELARTLQLVVLDADTINHPSQLGKTSLAPIIVYVKITSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPSEMFDIILDENQLEDACEHMADFLEAYWRSSHPPSCSSSDLELTDPPTATLPAAPTPASGVQGESNDEERPIRTESSKRAPHIHHRSSSTRTEHHNHHHHHHHHHNNRAKGISRQETLDSETPESRESKDSAHTEPHDLGEGHPQQRHEPLPQRDHNHHHHHHRSGGGDEAGHGTAHHRCKEREQDHNERNRQRSHHHHRPAREHHHHHEQDREGVVGPKKRGEAAGEWTRDSYIHQ","proteome":"UP000694548","gene":"CACNB2","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005245","name":"voltage-gated calcium channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0070588","name":"calcium ion transmembrane transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005891","name":"voltage-gated calcium channel complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"2dd7649e7ff0f048a9f2a359d76bba6b148689dd","counters":{"domain_architectures":9016,"entries":19,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"pfam":2,"cathgene3d":2,"ssf":2,"profile":1,"cdd":1,"smart":1,"panther":1,"prints":2,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":9016}}}