{"metadata":{"accession":"A0A8C6JLW2","id":"A0A8C6JLW2_MELUD","source_organism":{"taxId":"13146","scientificName":"Melopsittacus undulatus","fullName":"Melopsittacus undulatus (Budgerigar)"},"name":"Ubiquitin-associated and SH3 domain-containing protein B","description":["Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination"],"length":650,"sequence":"MAQRGQPAPHAMAAKEELYSKVIPRRNRQHRSGTIKHGSSLEILLSMGFPKARAQKALASTGGRSVQAACDWLFSHVGDPFLDDTLPREYVLYLRPTGPLAQKLSEFWQQSKQICGKNKAHNIFPHITLCQFFMCEDSKVDALTEALQATVMRWKCKFPAPLPLELYTSSNFIGLFVKEESAEVLKKFAADFAAEAASKADVHVEPHKKQLHVTLAYHFQTSHLPTLEKLAQNIDVKLGCDWVAAIFSRDIRFVNHETLQVIYPYTPQNDDELELVPGDFIFMSPVEQTSTSEGWIYGISLATGCSGLLPENYITKADECGTWVFHGSYSILNTTSSPSLQAFTDGALERRQQEDQGPGDTGPLTIICQNVQPLRITSQPGPQKRCLFVCRHGERMDVVFGKYWLSQCFDAKGRYMRSNLNMPHSLPQRSGGFRDYEKDAPITVLGCTQARLVGEALLETNTIVDYIYSSPSLRCVQTAHNILKGMQQENNLKIRIEPGLFEWTKWVSGNTLPAWIPPVDLAAATLSVDTTYRPHIPVSKLVVSESYDTYISRSYQVTKEIISECKGKGNNILIVAHASSLEACTCQLQGLSPQNSKDFVQMVRKIPYLGFCSCEELGDTGVWQLTDPPILPLTHGPTGGFNWRETLLQE","proteome":"UP000694405","gene":"LOC101877487","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"d421ce923dc2eb710f48a61516fd1c7ec739a028","counters":{"domain_architectures":1718,"entries":28,"isoforms":0,"proteomes":1,"sets":6,"structures":0,"taxa":1,"dbEntries":{"ssf":4,"profile":2,"smart":2,"cdd":3,"cathgene3d":4,"pfam":3,"panther":1,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":1718}}}