{"metadata":{"accession":"A0A8C6F1D4","id":"A0A8C6F1D4_MONMO","source_organism":{"taxId":"40151","scientificName":"Monodon monoceros","fullName":"Monodon monoceros (Narwhal)"},"name":"Tumor protein 63 (p63)","description":["Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes"],"length":501,"sequence":"MLYLENNAQAQFSEYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNTLTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSLVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE","proteome":"UP000694561","gene":"TP63","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003700","name":"DNA-binding transcription factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0000976","name":"transcription cis-regulatory region binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051262","name":"protein tetramerization","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006915","name":"apoptotic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"971a6e93f680f44c0f4c7c1131009890cae28dcd","counters":{"domain_architectures":2261,"entries":25,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"pfam":3,"ssf":3,"cdd":2,"smart":1,"panther":1,"prosite":1,"prints":1,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":2261}}}