{"metadata":{"accession":"A0A8C6A251","id":"A0A8C6A251_MARMA","source_organism":{"taxId":"9994","scientificName":"Marmota marmota marmota","fullName":"Marmota marmota marmota (Alpine marmot)"},"name":"Exopolyphosphatase PRUNE1","description":["Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization"],"length":422,"sequence":"MVSALALAFYLTKTNEAEEVFIPVLNIKRSELPLRGDNVFFLQKIQIPETILIFRDEIDLHALHQAGQLTLILVDHHVLPKSDAALEEAIVEVLDHRPIEQKHCPLCHVSVELVGSCATLVAERILQGAPEILDRQTAALLHGTIILDCVNMDIKIGKATPKDNEYVEKLEALFPDLPKRNDIFDFLQKAKFDVSGLTTEQILRKDQKTIHRQGTKVAISAVYMDLEAFLQRPNLLADLSAFCQAHSYDALVAMTIFFNAHNEPVRQLAIFCPHVALRMMICEVLERSHSPPLKLTPVPNTHPNLQAYLQGNTQVSRKKLLPLLQEALSTYFDSTKIPSGQPETVGVSREQVDKDLDRAGHALISGLSQDEEDPPLPPTPMNSLVDECPLDQGLPKLSAEAVFEKCSQISLSQSTTASLSNK","proteome":"UP000694407","gene":"PRUNE1","go_terms":[{"identifier":"GO:0016462","name":"pyrophosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005737","name":"cytoplasm","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4666e48c38cf2b003f8ebbefc2ecf2e07bf34761","counters":{"domain_architectures":1442,"entries":9,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":1,"smart":1,"panther":1,"pfam":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":1442}}}