{"metadata":{"accession":"A0A8C5LCA7","id":"A0A8C5LCA7_JACJA","source_organism":{"taxId":"51337","scientificName":"Jaculus jaculus","fullName":"Jaculus jaculus (Lesser Egyptian jerboa)"},"name":"Histamine H2 receptor","description":["The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase"],"length":414,"sequence":"MESNGTTASCCLNSAVFKVSLSVILTLLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSFKWSFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVTVSLIFIWVISITLSFLSIHLGWNSRNETRRSEDKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKIAREQARKINHISSWKAATIREHKATVTLAAVMGTFIICWFPYFTAFVYRGLKGDDAINEVFEAIVLWLGYANSALNPILYAALNRDFRTAYQQLFCCRLASHRSHKTSLRLNNSLLSRSQSPEAKWQEERPLKLQVWSGTDVTATQRASDRKPARSCTRCSGNLLSCCKSLWGLQFLQQSPSGEQSGEPLSEENVRTPSEETVRACEAV","proteome":"UP000694385","gene":"Hrh2","go_terms":[{"identifier":"GO:0004930","name":"G protein-coupled receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0004969","name":"histamine receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0001696","name":"gastric acid secretion","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0045907","name":"positive regulation of vasoconstriction","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"587fa3dbe4504dc051049f3cca904dd9ab631b87","counters":{"domain_architectures":394800,"entries":12,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"smart":1,"pfam":1,"profile":1,"panther":1,"prosite":1,"prints":2,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":394800}}}