{"metadata":{"accession":"A0A8C4KUI5","id":"A0A8C4KUI5_EQUAS","source_organism":{"taxId":"83772","scientificName":"Equus asinus asinus","fullName":"Equus asinus asinus"},"name":"Protein S100","description":["Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9. Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis. Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels. Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes. In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors"],"length":101,"sequence":"MAYPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMSNLDSNKDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK","proteome":null,"gene":"S100A4","go_terms":[{"identifier":"GO:0046914","name":"transition metal ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005509","name":"calcium ion binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"9fbe415715d177c71b45cd24325edde000517727","counters":{"domain_architectures":10240,"entries":16,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"cdd":1,"ssf":1,"smart":2,"pfam":1,"profile":1,"panther":1,"prosite":2,"interpro":6},"proteome":0,"taxonomy":1,"similar_proteins":10240}}}