{"metadata":{"accession":"A0A8C4E8G8","id":"A0A8C4E8G8_DICLA","source_organism":{"taxId":"13489","scientificName":"Dicentrarchus labrax","fullName":"Dicentrarchus labrax (European seabass)"},"name":"Mediator of RNA polymerase II transcription subunit 16","description":["Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors"],"length":645,"sequence":"RHTHLHTAAAQTQSPTRTCRTDTPASYRTSLIVFVCFSDVSHMIHIIDTEHPWDVYSINSTHSEVISCLEWDQSGSKLLSADGDGQIKCWSMSDHLVNSWESVLSSSVDGDPIVALSWLHNGVKLALHVEMSGSTNFGEKFSRVKFSPSLTLFGGKPMEGWLAVTVSGLVTVSLLKPGGALLTASESLCRLRGRVALADIAFTGGGNIVVAATDGSSSSPVQFYKVVVSVVSEKCRIDTELLPSLFLRCTTDPLRREKYPAVTHLKFLTRENSEQVLLCASNQSGSIVECWSLRKEGLPVNNIFQHRSPVVGEKQPTILKWRILTTTNDLERVSAVALPKLPISISNTDLKVASDTKFCPGLGLALAFHDGSIQILHRLSLHTMGVFYGSSTSSSGQRPGDESAIKRQRTGGPALHFKALQFSWTSLALAGVDNHGKLHMLRVSPSMGQVLEMNTTLRHLLFLLEYCMVTGYDWWDVLLHVQPTMVHNLVEKLHEEYMRQNQALQQVLATRIVAVKASLCKLSTATAARACDFHAKLLLIAISSTLKSLLRPHVLNTPDKSPGDRLTEICAKNSDTDIDKVMINLKTEEFVLDGPPLQSLQQLIQWVGDFVLYLLANLPNQVSQREHSDKFRLTEEQKLEHAQHW","proteome":"UP000694389","gene":"MED16","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016592","name":"mediator complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"2910ca613b44d95dc4b3be8a6d33d97427e64e26","counters":{"domain_architectures":145,"entries":14,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"smart":1,"profile":2,"pfam":2,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":145}}}