{"metadata":{"accession":"A0A8C4DQ38","id":"A0A8C4DQ38_DICLA","source_organism":{"taxId":"13489","scientificName":"Dicentrarchus labrax","fullName":"Dicentrarchus labrax (European seabass)"},"name":"non-specific serine/threonine protein kinase","description":["Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz. Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis"],"length":493,"sequence":"MENKDKVQMRNHPRRQLKKLSEDSLTKQPEEVFDVLEKLGEGSYGCVFKAHYKETGEIVAIKQVPVESDLQEIIKEISIMQQCNSPHVVRYYGSYFKNSDLWIVMEYCGAGSVSDIIRLRNKTLTEEEIATIVHSTLKGLEYLHFMRKIHRDIKAGNILLNSEGQAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRNPDQWSPSFREFVTQCLVKNPENRATATQLLQHPFIKSAKPNSILRALITDAMEIKLKRQEEAEQREQDAEDEDNSDEDEVDQGTMVRAGTDDSGTIRAAGSLSGTARTMIEHEDTGTMQSQLGTMVINSDDEDEEEAGTMKRRDETMQPAKPSFLEYFEQKEKEANSHNDGGGRGENNADNRKLPAEGDLQVVSTWSVEELRLRLASLDPQMEQEIEEIRQRYQAKRQPILDAIEAKKRRQQNF","proteome":"UP000694389","gene":"LOC127371570","go_terms":[{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004674","name":"protein serine/threonine kinase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"f661b271fc0d7852498aeeba81005c4217032105","counters":{"domain_architectures":2785,"entries":18,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"cdd":2,"smart":1,"profile":2,"ssf":1,"pfam":2,"panther":1,"prosite":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":2785}}}