{"metadata":{"accession":"A0A8C3M6E6","id":"A0A8C3M6E6_GEOPR","source_organism":{"taxId":"87175","scientificName":"Geospiza parvula","fullName":"Geospiza parvula (Small tree-finch)"},"name":"Protein VAC14 homolog","description":["Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes"],"length":779,"sequence":"MNAERDLSPLTPGVVRALTDKLYEKRKVAALEIEKLVREFVAQNNTSQIKHVIQILSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGSVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNQFDLVGFIPLLRERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNSKEIRKMCEVALGEFLKEIKKNPSSVKFAEMANILVIHCQAADDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLSYDDRKKNIKEVANVCNQSLMKLVIPEDDEMDEAKPSMTIPAEPTSEESLSRPEAVTAGSLDASGDSSNSGVFTVTSCERIQVTLNLDGIVQVLDYHLSDTSIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLRTLSDESDEVILKDLELLAEIASSPAGQTEEGHGPSDGSDVRPGPVELHVPARPGQLSSSSTKGLECSPSTPTMNSYFYKFMINLLKRFSSERKLLEARGAFIIRQLCLLLNAENIFHSMADILLREEDLKFASTMVHTLNTILLTSSELFQLRNQLKDLKTPESRNLFCCLYRSWCHNPVTTVSLCFLTQNYKHAYDLIQKFGDLEVTVDFLTEVDKLVQLIECPIFTYLRLQLLDVKNNPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELMQTTDNSKPSTSFKRTAASNIDYTELLQHFEKVQNKHLEARHQRAGRAEQLDRRVVL","proteome":"UP000694382","gene":"VAC14","go_terms":[{"identifier":"GO:0006661","name":"phosphatidylinositol biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0070772","name":"PAS complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"3ef46bdb6099f1f76d6b7728ccc114eda7db1a5a","counters":{"domain_architectures":4175,"entries":9,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":2,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":4175}}}