{"metadata":{"accession":"A0A8C3F6D3","id":"A0A8C3F6D3_CHRPI","source_organism":{"taxId":"8478","scientificName":"Chrysemys picta bellii","fullName":"Chrysemys picta bellii (Western painted turtle)"},"name":"Pseudouridylate synthase TRUB1","description":["Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity. Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation"],"length":289,"sequence":"MAEEVHGKLGHVMANPAAKLLSLSGLFAVYKPKGPTSANVLNQLKEKLLAEAGIQKCVRKRKKQILKIGHGGTLDSAAAGVLVVGIGKGTKMLGNILAGSKKYLAIGELGKATDTLDATGKVTEEKPYDQITKEDLERVLQKFTGDIMQVPPLYSALKRDGQRLSSLMKKGEAVEAKPARPVTVYSLSLQNFQSPLFTLDVECGGGFYVRSLVSDIGKELSSCANVQELTRTKQGPFTLEEHALHEDKWTIDEIAQSLEHCMSFLAVEPSLKKLKTEHSEESTVNCEDK","proteome":"UP000694380","gene":"TRUB1","go_terms":[{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009982","name":"pseudouridine synthase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0001522","name":"pseudouridine synthesis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0009451","name":"RNA modification","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006396","name":"RNA processing","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"28a6c0c889cc202e14ae965a0574b1a1c3b7da3c","counters":{"domain_architectures":6466,"entries":9,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"panther":1,"hamap":1,"ncbifam":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":6466}}}