{"metadata":{"accession":"A0A8C2MMI3","id":"A0A8C2MMI3_CRIGR","source_organism":{"taxId":"10029","scientificName":"Cricetulus griseus","fullName":"Cricetulus griseus (Chinese hamster)"},"name":"Adhesion G-protein coupled receptor D1","description":["Adhesion G-protein coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens. Also activated by methenolone drug. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength"],"length":903,"sequence":"MRDLPTLPCHWVCLLWSFCSFQVCGTQPRAQEHPGFAVLASASHYWPLENVDGILELQDTTGALRTHNLTVPPSHNATFVFTNDSAYSNFSATVDIMEGKVNKGIYLKEEKGVTFLYYGSYKSSCISNPAQCGPEGVTFSFFWKTQEEQPRPAPYAYGGQVISDGFKVCSSGGKGSVELYTRDNSMTWKATFNPPGPYWTHVLFTWKSKEGLKVYVNGTLSTSDPSGKVSHTYGEPHVNLVIGSEQDQTKRYENGAFDEFIIWERALTPDEIKMYFTAAIGKHSLLSSTPPAMPTAHSMVPTDAYHPIITNLTEERKCFQRPETVLRYLQNVSLSLPNKSLSEETALNLTQTFLRTVGEVLLLPSWTHVSEDNTMTLGLVDTIDTVMGHISANLQSREPHITLTGSSSMADFFVAKVLPPALSAPHYRFPAHGHSYIEIPREALHGKAWTTIVGLLYHSMHYYLNNIPPASTKIPEAVNCRDCLLSVASHLISLEVSPPPTLSQNLSGSPLITVHLRHKLTHKQYVDATNESNDLFLYCAFLNFSSGEGIWSSQGCALREGNLTHSVCHCTHLTNFAILMQVVPLQLTRGHQVALSSISYVGCSLSVLCLAATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRVEPGTVPCQVLAILLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHLYYYGIGWGCPLLICIISISSSMDSYGTNDSCWLSLGSGAIWAFVGPALLVIVVNIVILVAVTRVISHVSTDNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVSDRALVFQYMFAVLNSLQGLFIFLFHCLLNSEVRAAFKHKTKVWSLTSSSARTTNTKPFSSDIVNGTRPGTASTKLSPWDKSSHSAHRVDLSAV","proteome":"UP001108280","gene":"Adgrd1","go_terms":[{"identifier":"GO:0004930","name":"G protein-coupled receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0004888","name":"transmembrane signaling receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007166","name":"cell surface receptor signaling pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e6ecd940feaf4815481406bfc2e7db50b9700357","counters":{"domain_architectures":1235,"entries":22,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"profile":3,"cathgene3d":3,"pfam":3,"smart":1,"panther":1,"prints":1,"prosite":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":1235}}}