{"metadata":{"accession":"A0A8B9KAM3","id":"A0A8B9KAM3_ASTMX","source_organism":{"taxId":"7994","scientificName":"Astyanax mexicanus","fullName":"Astyanax mexicanus (Blind cave fish)"},"name":"E3 ubiquitin-protein ligase","description":["E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates"],"length":334,"sequence":"MSPTVRLQPVYSWKGVLKLFTCIAARTASKPKEVHTFQEKKIALLGNHMDEEMSRQTATALPTGTSKCAPSQRVPTLSGTTASNSDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEVTLPHTDKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLLHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC","proteome":null,"gene":"siah1","go_terms":[{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006511","name":"ubiquitin-dependent protein catabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0007275","name":"multicellular organism development","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005737","name":"cytoplasm","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"3f468851f694fe28c25bcae276188b81757b837b","counters":{"domain_architectures":5800,"entries":19,"isoforms":0,"proteomes":0,"sets":5,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"cdd":2,"pfam":3,"profile":2,"panther":1,"interpro":7},"proteome":0,"taxonomy":1,"similar_proteins":5800}}}