{"metadata":{"accession":"A0A8B9GZ69","id":"A0A8B9GZ69_ASTMX","source_organism":{"taxId":"7994","scientificName":"Astyanax mexicanus","fullName":"Astyanax mexicanus (Blind cave fish)"},"name":"Mitogen-activated protein kinase kinase kinase 1","description":["Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway"],"length":1386,"sequence":"RVGASGKSRPGFGAPAAGLAKVLQLSGADFLSLFFGRDMENKETLRGLQKMEDRPEERMIREKLKATCMPTWKHEWLERRNRRGPVVVKPVPLRPDGSEAGRQGPESGSDSMNSSSSQSRGRRSPSPGPSSSSTSSSSTRTSKPESPGVRRKRASPVPFQSGRVTPPRRAPSPDGFSPYSPEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQTCSCGRGAFCIHVLFVMLRVFQLESSDPLLWRKTLKNFEVESLFQKYHNRRSSRIKAPSRNTIQKFVSRMSNSHTNCTSSSSPSSNESSMKDEEEQMCPICLLDMLDEESLTVCEEGCRNKLHHHCMSIWAEECRRNHEPLICPLCRAKWKSHDFYSHEPASTVESSTSRSQSQVPSSAASSSSSPHAEGQRASQEGDFSLPHYGVQQIPQTYKELAEPWIKVFGMELVGCLFSRNWNIREMALRRLSHDVSGALLLANGERSLASAGAGAGAGLGAAGSEVSGDVVVESCCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLSERSRLQQLLRPVVETILVKCADANSRTSQLSVSTLLELCKGQLGELAVGREILKAGSIGIGGVDYVLNCILGSQTESNNWQALLGRLCLIDRLLLEFPAEFYPHIVSASDCGQPQNQVERYQKLLPLLSFALQSIDNSHSMVGKLSRRVFLSAARMVARVPHIFVKLLDMLSVTSSTHYARMRRRLLAIAEEMDILEAIHLGLEDAQMAPSQHCDAFLEPSAPHNSPITTERNSPTLGLQQLAKAGRGGMASAKPADEIADRLAAITTTSSSSNSYADQPKPPVQLRPRPMSQCLNSPSSSQAPTLPSPSTSHAPAFPPDNPKARAPGFVLGKFTQSSPGAQRKFPIQKGGTCGGTNKDLEKLPSPVFPPSRPLPPTQVHRPRPSRPSPSASSECGAKASCLGAKSNMKLDLQDHQPMDSTSTVFVPSDDAVFTPVEEKFRGLDASAELNSSMEDLLEASMPAADSTVTFQSEVAVLSPEQAGMSDDAYSEDMTQNQKCKEKMEAEEEEALAIVMAMSESQDALPIIPQLQVDKGEDVIIIQVDTPETLPGHTKAKQPYREGAEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKNNYNLFVEWMAGGSVSHLLNKYGAFKEGVIINYTEQLLRGLAYLHENQIIHRDIKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMSCAKPPWNAEKHSNHLALIFKIASATTAPTIPPQLSPGLRDVTLRCLELQPADRPPSRELLKHPIFRLNW","proteome":null,"gene":"map3k1","go_terms":[{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"695084acc4f1f71df64564f4d8fd9bede882449c","counters":{"domain_architectures":776,"entries":28,"isoforms":0,"proteomes":0,"sets":4,"structures":0,"taxa":1,"dbEntries":{"pfam":3,"profile":3,"cathgene3d":3,"ssf":3,"cdd":2,"smart":1,"panther":1,"prosite":2,"interpro":10},"proteome":0,"taxonomy":1,"similar_proteins":776}}}