{"metadata":{"accession":"A0A8B8YHN7","id":"A0A8B8YHN7_BALMU","source_organism":{"taxId":"9771","scientificName":"Balaenoptera musculus","fullName":"Balaenoptera musculus (Blue whale)"},"name":"Thioredoxin reductase 1, cytoplasmic","description":["Reduces disulfide protein thioredoxin (Trx) to its dithiol-containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. A selenocysteine residue at the C-terminal active site is essential for catalysis. Also has reductase activity on hydrogen peroxide (H2O2)"],"length":530,"sequence":"MQGKGRRLNACLSRAEVSLSRAYQEGGLQNLLKMNGSEDLPESYDYDLIIVGGGSGGLAAAKEAAKYNKKVMVLDFVTPTPLGTTWGLGGTCVNVGCIPKKLMHQAALLGQALRDSRNYGWNVEEIVKHDWERMTEAIQNHIGSLNWGYRVALREKKVTYENAYGQFVGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVVAKSTDSDVTIEGEYNTVLLAIGRDACTREIGLENVGVKLNEQTGKIPVTDEEQTSVPYIYAIGDVLEGKLELTPVAIQAGRLLVQRLYGGSAVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVFHSYFWPLEWTIPSRDNNKCYAKIVCNIKDGERVVGFHILGPNAGEVTQGFAAALKCGLTKDQLDGTIGIHPVCAEVFTTLSVTKRSGGNILQTGC","proteome":"UP000694857","gene":"TXNRD1","go_terms":[{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0050660","name":"flavin adenine dinucleotide binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0045454","name":"cell redox homeostasis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004791","name":"thioredoxin-disulfide reductase (NADPH) activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016668","name":"oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"786e6e0af388e0b289d71a3e92e80414d4c849c2","counters":{"domain_architectures":79025,"entries":20,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"pfam":2,"cathgene3d":2,"pirsf":1,"panther":1,"ncbifam":1,"prints":2,"prosite":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":79025}}}