{"metadata":{"accession":"A0A8B8Y9Y2","id":"A0A8B8Y9Y2_BALMU","source_organism":{"taxId":"9771","scientificName":"Balaenoptera musculus","fullName":"Balaenoptera musculus (Blue whale)"},"name":"Ragulator complex protein LAMTOR2","description":["As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2"],"length":125,"sequence":"MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS","proteome":"UP000694857","gene":"LAMTOR2","go_terms":[{"identifier":"GO:0005085","name":"guanyl-nucleotide exchange factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0060090","name":"molecular adaptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0032008","name":"positive regulation of TOR signaling","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"3da18beb9bf52065460305891d4df7f1d629bfeb","counters":{"domain_architectures":27690,"entries":7,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"smart":1,"pfam":1,"panther":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":27690}}}