{"metadata":{"accession":"A0A8B8T8P4","id":"A0A8B8T8P4_CAMFR","source_organism":{"taxId":"419612","scientificName":"Camelus ferus","fullName":"Camelus ferus (Wild bactrian camel)"},"name":"Serine/threonine-protein kinase MRCK beta","description":["Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation"],"length":1712,"sequence":"MSAKVRLKKLEQLLLDGPWRNESSLSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITTLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNVEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQSSTLTKDEGVQRDLENSLQVEAYERRIRRLEQERLELSRKLQESTQTVQSLHGSARALGSSARDKEIKKLNEEIERLKNKIADSNRLERQLEDTVTLRQEHEDSTLRLKGLEKQYRVVRQEKEEFHKQLIEASERLKSQARELKDAHQQRKLALQEFSELNERMAELRSQKQKLSRQLRDKEEEVEVAMQKIDSLRQEARRSDKCRKELEAQLEDAVAEASKERTLREHSENFSKQIESELEALKMKQGGRGPGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLALQKEVLVLRDKLEKSKRERLSEVEEAVGTLRDKHERERAMLFEENKKVTAENEKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELETLRSSSLGSRTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEELRKVKDSNLAFESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNAAPLAHDLTFRTSSTSEQETQAPKPEASPPVSGAASMDQQEDTARAPQRPPPVPLPATQALALAGPKPKAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDSAPQVCPIPPEQSKRPLGVDVQRGIGTAYKGYVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPGVVASQVLDLRDDEFSVSSVLASDVIHASRRDIPCIFRVTASLLDTPSRTSSLLILTENENEKRKWVGILEGLQSILHKNRLRSQVVHIPQEAYDSSLPLIKAVLTAAIVDGERVAVGLEEGLYTIEVTRDVIVRVADYKKVYQIELAPKEKVAVLLCGRNHHVHLCPWSAFDGVESNIDVKLPETKGCQLIATGTLKKGSPTCLFVAVKRLVLCYEVQRTKPFHRKLSEAVAPGTVQWMAVLKDKLCVGYPSGFSLLSAQGDGQALNLVNPNDPSLTFLSQQSFDALCAVELKSEEYLLCFSHMGLYVDPQGRRSRTQELMWPAAPVACSCSSSHVTVYSEYGVDVFDVRTMEWVQTIGLRRIRPLNSEGSLNLLNCEPPRLIYFKSKSAGAILSVPDTSDNSKKQMLRTRSKRRFVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLSAVPPSQEERPGPAPASLPRQPPPRNKPYISWPSSGGSESGVAVPLRSMSDPDQDFDKEPDSDSTKHSTPSNSSNPSGPPSPNSPHRSQLPLEGLEQPAYDA","proteome":"UP000694856","gene":"CDC42BPB","go_terms":[{"identifier":"GO:0004674","name":"protein serine/threonine kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"b0e583d90c33df2b089e551aa86c0d2697d5cf68","counters":{"domain_architectures":483,"entries":52,"isoforms":0,"proteomes":1,"sets":8,"structures":0,"taxa":1,"dbEntries":{"cdd":4,"cathgene3d":5,"ssf":3,"pfam":6,"smart":6,"profile":6,"panther":1,"prosite":3,"prints":1,"interpro":17},"proteome":1,"taxonomy":1,"similar_proteins":483}}}