{"metadata":{"accession":"A0A8B7VR98","id":"A0A8B7VR98_CASCN","source_organism":{"taxId":"51338","scientificName":"Castor canadensis","fullName":"Castor canadensis (American beaver)"},"name":"ATP-binding cassette sub-family C member 8","description":["Regulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release. In pancreatic cells, it forms KATP channels with KCNJ11; KCNJ11 forms the channel pore while ABCC8 is required for activation and regulation"],"length":1581,"sequence":"MPLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHIHHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESRHLHLYMPAGMAFMAAVTSVVYYHNIETSNFPKLLIALLIYWTLAFITKTIKFVKFYDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYRRLCEAFDAQARKDTQSAQGARAIWRALCHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEFLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGDMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFCTRVEMTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKESDFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPREPAPQSQVSKYQAVPLKVVNRKHPAREDSRDLMGPLQRLAPSTDGDADNCCVQIIGGFFTWTPDGIPTLSNVTIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKISGAVFWNSLPDGETGENPSPERETTADSDVRKRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTSVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSEYQLFEHWKTLMNRQDQELEKETVMERKATEASQGLPRAMSSKDGFLQDEEEEEEDAAESEEEDNLSSVLHQRAKIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLSPAARNCSLSQECTLDQTVYALVFTVLCSLGIVLCLITSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSSNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHREISAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIVIDGIDISKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKPVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGTILEFDKPEKLLSQKDSIFASFVRADK","proteome":"UP001732720","gene":"Abcc8","go_terms":[{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0140359","name":"ABC-type transporter activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0055085","name":"transmembrane transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016887","name":"ATP hydrolysis activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008281","name":"sulfonylurea receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006813","name":"potassium ion transport","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"4007c79a317d9c2b61b5291112faeb62d6487d24","counters":{"domain_architectures":71956,"entries":25,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"profile":2,"cdd":3,"pfam":2,"smart":1,"panther":1,"prints":2,"prosite":1,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":71956}}}