{"metadata":{"accession":"A0A8B7USV2","id":"A0A8B7USV2_CASCN","source_organism":{"taxId":"51338","scientificName":"Castor canadensis","fullName":"Castor canadensis (American beaver)"},"name":"Prostaglandin reductase 2","description":["Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation"],"length":300,"sequence":"MRCRMNEDTGSDYLVPWQLSQVVDGGGIGIIEDSKHTSLTKGDVVTSFFWPWQTKAVLDGSILEKVDPQLVGGHLSYFLGAIGMPGLTSLIGIQEKGHITAGSNQTMVVSGAAGACGSLGGQIGRLLGCSRVVGICGTHEKCLLLTSELGFDAAINYKKGNVAEQLQESCPAGVDVYFDNVGGDISDTVISQMNQNSHIILCGQISQYNKDVPYPPPLPSAVEAIQKERNITRERFLVLNYKDKFEPGILQLSQWFKEGKLKIKETVINGLENMGAAFQSMMTGGNIGKQIVCISEDTSL","proteome":null,"gene":"Ptgr2","go_terms":[{"identifier":"GO:0047522","name":"15-oxoprostaglandin 13-reductase [NAD(P)+] activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006693","name":"prostaglandin metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016628","name":"oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"5868aa2108b93d49c5c92d05158401122f1a86a6","counters":{"domain_architectures":28175,"entries":14,"isoforms":0,"proteomes":0,"sets":3,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cathgene3d":2,"cdd":1,"pfam":2,"panther":1,"interpro":6},"proteome":0,"taxonomy":1,"similar_proteins":28175}}}