{"metadata":{"accession":"A0A8B7UPI1","id":"A0A8B7UPI1_CASCN","source_organism":{"taxId":"51338","scientificName":"Castor canadensis","fullName":"Castor canadensis (American beaver)"},"name":"Proteasome activator complex subunit 3","description":["Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition"],"length":265,"sequence":"MEKWILKKIKYLQSGGLSPSHYNLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY","proteome":null,"gene":"Psme3","go_terms":[{"identifier":"GO:0008537","name":"proteasome activator complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"10e2f3fb4bf16e242b53ca9f6ffe5ab601de5694","counters":{"domain_architectures":3473,"entries":12,"isoforms":0,"proteomes":0,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":1,"pfam":2,"panther":1,"interpro":6},"proteome":0,"taxonomy":1,"similar_proteins":3473}}}