{"metadata":{"accession":"A0A8B7T0G7","id":"A0A8B7T0G7_HIPAR","source_organism":{"taxId":"186990","scientificName":"Hipposideros armiger","fullName":"Hipposideros armiger (Great Himalayan leaf-nosed bat)"},"name":"Solute carrier family 22 member 17","description":["Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis"],"length":708,"sequence":"RRVWTEGSADVGRGGESGGRGGESSAKIAESKEAPAAAELQSGVSSASVSGQWARHWARRQRNLSVRPGRAPAFGKLAPRVATGTSEPNGGGSSKIDSTVEIAPSPNGVGTLEDAAPTEQLQGEREREREREGEGDAGGDGLGSSLSLAVPPGPLSFEALLAQVGALGGGQQLQLGLCCLPVLFVALGLASDPIFTLAPPLHCHYGGFSPNASGWEQSPNASGVGVASAALAASAASRVSTSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLLMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAGILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLMRQPPPNRCDHVPLLATPNPAL","proteome":"UP000694851","gene":"SLC22A17","go_terms":[{"identifier":"GO:0022857","name":"transmembrane transporter activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0055085","name":"transmembrane transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"03fa97b454336937c9960a7f5034cde92ca2cdaa","counters":{"domain_architectures":276159,"entries":11,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"profile":1,"cdd":1,"cathgene3d":1,"ssf":1,"panther":1,"pfam":1,"prosite":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":276159}}}