{"metadata":{"accession":"A0A8B7QVY9","id":"A0A8B7QVY9_HIPAR","source_organism":{"taxId":"186990","scientificName":"Hipposideros armiger","fullName":"Hipposideros armiger (Great Himalayan leaf-nosed bat)"},"name":"Suppressor of fused homolog","description":["Negative regulator in the hedgehog/smoothened signaling pathway that acts by sequestering the GLI (GI1, GLI2 and GLI3) transcription factors in the cytoplasm. When smoothened signaling is initiated, GLI transcription factors dissociate from SUFU, translocate to the nucleus and activate expression of target genes. In absence of smoothened signaling, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of full-length GLI3 into transcription repressor GLI3R: SUFU participates to GLI3 processing by promoting recruitment of GSK3B to GLI3. May also act as a negative regulator of beta-catenin signaling. Required for normal embryonic development. Required for the proper formation of hair follicles and the control of epidermal differentiation"],"length":516,"sequence":"MAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDSRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHAAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINPQRQNGLTHDRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDLTSPEEVVKETLEMLNGLISLCLPTTPSPHKDTQQTELPAPENLAEEAARAFSSNFPKSTTGLKRS","proteome":"UP000694851","gene":"SUFU","go_terms":[{"identifier":"GO:0140297","name":"DNA-binding transcription factor binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0045879","name":"negative regulation of smoothened signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"8e72a211576f0b2ecbde55f94782407c47cf685a","counters":{"domain_architectures":1588,"entries":12,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"pfam":2,"cathgene3d":1,"panther":1,"pirsf":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":1588}}}