{"metadata":{"accession":"A0A8B7QL98","id":"A0A8B7QL98_HIPAR","source_organism":{"taxId":"186990","scientificName":"Hipposideros armiger","fullName":"Hipposideros armiger (Great Himalayan leaf-nosed bat)"},"name":"DNA replication licensing factor MCM7","description":["Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity"],"length":719,"sequence":"MALKDYALEKEKVKKFLQEFYQDDEFGKKQFKYGNQLVRLAHREQVALYIDLDDVAEEDPELVDSICENTKRYARLFADTVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGAARSPQNQYPPELMRRFELYFQGPSSNKPRVIREVRADSLGKLVTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSKFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILCSGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTKEELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVTGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPAQFEPLDMKLMRRYIAMCQEKQPTVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDTVEKEDVNEAIRLMEMSKDSLLSDKGQTARTQRPADVIFATVRELVSEDRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNTARTRITFV","proteome":"UP000694851","gene":"MCM7","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003678","name":"DNA helicase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006270","name":"DNA replication initiation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0042555","name":"MCM complex","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0006260","name":"DNA replication","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4d94c12dca905cb5a5db8ad36b636b9785c08d98","counters":{"domain_architectures":3017,"entries":29,"isoforms":0,"proteomes":1,"sets":6,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"pfam":5,"ssf":2,"smart":2,"profile":1,"cdd":1,"panther":1,"prosite":1,"prints":2,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":3017}}}