{"metadata":{"accession":"A0A8B7GG25","id":"A0A8B7GG25_MICMU","source_organism":{"taxId":"30608","scientificName":"Microcebus murinus","fullName":"Microcebus murinus (Gray mouse lemur)"},"name":"Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial","description":["Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes"],"length":280,"sequence":"MCLSIAFFPAVAAATGHTVVLVDQTEDILAKSRQGIEDSLRKVAKKKFAENPKAGDEFVEKTLSSISTSTDAAAVVHSTDLVVEAIVENLAVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPLMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAVRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIMDGWHELDVKDPMFQPSPALNKLVAEKKLGRKTGEGFYKYK","proteome":"UP000694394","gene":"HADH","go_terms":[{"identifier":"GO:0070403","name":"NAD+ binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006631","name":"fatty acid metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016616","name":"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4284d99bfe08e8b0f62de61d7ec240c3c8811a25","counters":{"domain_architectures":39081,"entries":17,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"pfam":2,"ssf":2,"pirsf":1,"panther":1,"prosite":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":39081}}}