{"metadata":{"accession":"A0A8B7B6Y9","id":"A0A8B7B6Y9_ORYAF","source_organism":{"taxId":"1230840","scientificName":"Orycteropus afer afer","fullName":"Orycteropus afer afer"},"name":"Wolframin","description":["Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism"],"length":929,"sequence":"MTATPKCYVLRLVLRMASAGARAADVPSGRRGCLRERPAGGPGRRSFQGAGRRIELSARGPQARARLNATASLEQERSNEPQARPGPHDTGDAAAAPAAPQAQHTQSQEGAANSELAKEDTVLPFEEVLEKAKGGDPKAQTEVARHYLRLASETDEELNSCTAVGWLVLAAKHGRREAVRLLRRCLADRKGITSENEQQVQELTSETELERAVRKAALVMYWRLNPRKEKRVAVSELLENVGQVDGHDGGTRPGPVPKALQKQRRMLERLVSSESKNYIAPDDFVEITKKYAKGIIPSGLCLPDGDGDDDDELAGRSPEDLPLHLKVVRYPLHTIMEIKEYLIDVASKAGMHWLSTIVPTHHLHALLVFFVLSNLTIDFFAFCIPLVVFYLSFLSMVICTLKVFQDSRAWESFRTLTDLLLRFEPGLDVEQAEGNFGWNHLEPYVHFLLSVFFVIFSFPVASKDWVPCSELALVAVFFTVTSYASLGTSAEPHTRRALATEVAAGLLSLLPTLPLDCQLLKLLSQTLLRVPLGRLVVLNLGVPCLLYLHLFYCFFRMARLRHFKGTYCYLVPYLVCFMWCELAVVLLLESTGLGLVRASVGYLLFVFALPMLVVGLGLLGLVQLARWVVSLELTKAAVTVLACGVPLLLLRWGAGARASVASALHSLTRSSMVKLILVWVSAVVLFCWFYVYRSEGMKVYNSTLTWPQYAALCGPRAWRETNMARTQILCSHLEGHRVTWTGRFKYVRVTEIDNSAEATINMLPFAVGDWLRCLYGEAYPSCGAGGAPTAEQELCRLKLLAQHRCHIKHWDRYKFELTVGMLRGSTNGTRSAEEDDVTKDIVLRASNEFRAVLLGLRQGSLVEFSTVLEGRLGSKWPVFELKAISCLNCPAQPSPAPRHVKLEHDWRSTVHGALKFAFNFFFFPFLSAT","proteome":"UP000694850","gene":"WFS1","go_terms":[{"identifier":"GO:0055074","name":"calcium ion homeostasis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005783","name":"endoplasmic reticulum","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"0296ed5605fa64fc38a3ffaee72c3b2b796ee8c4","counters":{"domain_architectures":1109,"entries":13,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"pfam":4,"panther":1,"prints":2,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":1109}}}