{"metadata":{"accession":"A0A8B7ABS8","id":"A0A8B7ABS8_ORYAF","source_organism":{"taxId":"1230840","scientificName":"Orycteropus afer afer","fullName":"Orycteropus afer afer"},"name":"Pseudouridylate synthase RPUSD4, mitochondrial","description":["Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Acts on position 39 in mitochondrial tRNA(Phe). Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing"],"length":375,"sequence":"MVAPSCVVPGLLVWGTGQRLDNFFILVSKLFCSAAAASRPLDAQRLAERLRAQKQEQKKEPVPANPVQRRVRELVRFTQQLQRVHPNVLAKALSRGILHQNKDLVVINKPYGVPVHGGPGVQLCINDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWEKEVAHQIQQLFKTRQVTKKYWAITVNVPVPSVGVVDIPIVEKEVQGQQQHHKMTLSPSYHMDNGKMVKVRTSRNAHTAVTQYQVLSSTLSSALLELQPITGVKHQLRVHLSFGLDCSILGDHKYSDWNKLAPQKLSVGTLKKLGLEQSKARHIPLHLHARQLILPALGSRKEDLNLVCKVPHFFVCSLRRLGLKMPSKDQTEDDQAGHLGAQ","proteome":"UP000694850","gene":"RPUSD4","go_terms":[{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009982","name":"pseudouridine synthase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0001522","name":"pseudouridine synthesis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0009451","name":"RNA modification","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7a8b2c7931b32bef9a49c533034053867e5cf2c1","counters":{"domain_architectures":77605,"entries":10,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"cdd":1,"panther":1,"pfam":1,"prosite":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":77605}}}