{"metadata":{"accession":"A0A8B6ZV35","id":"A0A8B6ZV35_ORYAF","source_organism":{"taxId":"1230840","scientificName":"Orycteropus afer afer","fullName":"Orycteropus afer afer"},"name":"Suppressor of cytokine signaling 1","description":["Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins"],"length":208,"sequence":"MVAHNQVAADNAISTAAEPRRRPESSSPSSAPVAPARPRPCPAAPAPGDTHFRTFRSHAEYRRITRTSALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRETFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI","proteome":"UP000694850","gene":"SOCS1","go_terms":[{"identifier":"GO:0035556","name":"intracellular signal transduction","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e16098dee2ddb77b6a79a81058967a7deadb45c6","counters":{"domain_architectures":6301,"entries":18,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"cdd":1,"ssf":2,"smart":3,"pfam":2,"profile":2,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":6301}}}