{"metadata":{"accession":"A0A803W8I2","id":"A0A803W8I2_FICAL","source_organism":{"taxId":"59894","scientificName":"Ficedula albicollis","fullName":"Ficedula albicollis (Collared flycatcher)"},"name":"Phosphoinositide phospholipase C","description":["The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function"],"length":638,"sequence":"MDEDRWFWNLIRNDFQTGKIDFEGCMRLFEKMNINFDVDHFKHIFKKTLDKHTEDIISMDDFRAIYRALVHRPEYEDLFKSYSTDGKILPDGQLLKFLVKEQFQTEADEATALEIIMKHEPIDEVRKKRQMSFEGFVRYMNSDECSVFKIQHKTVYQDMTQPLCDYYISSSHNTYLLSDQVMGPSHLWGYTSALLKGCRCLEVDCWDGNNEPMVYHGHTLTSRIPFRSVIHVIDKYAFMSSAYPLILSLENHCSPKQQEAMADCLKSILGEKLLSLPLGGDVNMTRLPSPEALKFKVLIKNKKVGTIEESLMRVDEDCHGEVEEISDSDAQSDDEDSDDTVPARLARSPSKRKGASPHSSVPPHKRTKVRRVKIALVLSDLVIYTKSQTFVSFDHSLQHQQCYENNSIGEVVARKLAKTSVKEFISHTTRFITRIFPKGSRASSSNYSPQDFWNIGCQMVALNFQTRGLPMELQDGKFLDNGACGYVLKPEFLRDCNTSFTPRNVGGYSKPMSLSIRLISGHQLPPSSLSKTNKADPIVQIEIYGVPEDQTRKKSSVARSNALCPKWNEMFNFTIQVPELALIRFCVEDEISLVNREFLGQYTLPVMCLNTGYRNVPLLSKDGARMEPASLFVHVWYY","proteome":"UP000016665","gene":"PLCZ1","go_terms":[{"identifier":"GO:0008081","name":"phosphoric diester hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006629","name":"lipid metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004435","name":"phosphatidylinositol-4,5-bisphosphate phospholipase C activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0035556","name":"intracellular signal transduction","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e36128bbf200eff3804e5cac40701d1a723cf418","counters":{"domain_architectures":3275,"entries":27,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"ssf":3,"pfam":4,"cathgene3d":3,"profile":3,"smart":3,"cdd":1,"panther":1,"prints":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":3275}}}