{"metadata":{"accession":"A0A803TIG6","id":"A0A803TIG6_ANOCA","source_organism":{"taxId":"28377","scientificName":"Anolis carolinensis","fullName":"Anolis carolinensis (Green anole)"},"name":"Metabotropic glutamate receptor 2","description":["Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate. Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling. Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization","G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity"],"length":807,"sequence":"MAFSPTLWILLVCPIVCHAASHNPSSSYSVTTKKEISLEGDLVIGGLFPVHEKGNPTEECGKINEHRGIQRLEAMLFALDEINKNQHILPGIKLGAHILDTCSKDTYALEQSLDFVRASLTRVDGSEHICPDGSYAIHDDVPQAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMSEILRFFNWTYVSTVASEGDYGETGIEAFELQARARNICIATSEKVGRSMNKKTFDGVIKALMQKPSAKVVVLFTRSEDARELLAAAQRINVSFTWVASDGWGALESVVAGSEPVAEGAITIELASYPVQEFAVYFRNLDPYNNSRNPWFREFWEHKFQCSFHHQNCSHFSLKTGKFEQESKIMFVVNAVYAMAHALHNMYQALCPNATKLCDSMKPVNGKRFYKEFMLNVTFDAPFRPSLDTKSTVRFDSCGDGIGRYNIFNYHRSNGRYHYQKVGYWAEGLILDTSLIPWVKTSIPVSQCSDPCKKNEMKSMQPGDMCCWICIPCQPYEYLVDEFTCQDCGPGYWPNETLNGCYELPQEYIRWKDVWAIGPVTISCLGFISTMFVFGVFAKNNDTPIVKASGRELCYILLTGVLMCYSMTFIFIAKPSTAVCTLRRLGLGTSFAVCYSALLTKTNRIARIFSGVKEGVQRPRFISPTSQVVICMALISCQLIIVVIWLMVETPGTRKETEPDKRYIVTLKCNNRDSSMLISLTYNVLLIVLCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVSNFLIRVGGGTS","proteome":"UP000001646","gene":"GRM2","go_terms":[{"identifier":"GO:0004930","name":"G protein-coupled receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"d483354507dd020195641425f6da794b4f2aa8c8","counters":{"domain_architectures":26142,"entries":25,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"ssf":1,"cathgene3d":2,"pfam":3,"profile":1,"panther":1,"prosite":3,"prints":3,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":26142}}}