{"metadata":{"accession":"A0A803KET6","id":"A0A803KET6_XENTR","source_organism":{"taxId":"8364","scientificName":"Xenopus tropicalis","fullName":"Xenopus tropicalis (Western clawed frog)"},"name":"Lymphocyte cytosolic protein 2","description":["Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells. Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK. In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation. Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses"],"length":550,"sequence":"MDFRSIPSCSEVSCWSPEALIEYFRAHNLRDCEKLVKKQGITGKRFLEMTENEIQKFPKVAVPMLIKIQQHMNKKDEKRGFFQKKTAIPRFPQETEFIPEDKEFSDSDSFEEDYESPNEFDDDDYERPASENEEDENENGDYEPPPPNIEDAHPPIFQLKPNVTNSPYADREFGNSTKNPPEPPKRPGNPGLPPNRGHTFPGYSPSSNQENRANTLGPSIDRTIKPSFEMTYPPNVGRGEFSQKFRKTIRQWRNAEIHCKSMPVLGKFKYKLQLKGWFTINLTFRKPPIPGKIQTGHAGISQQASEKLSNLIKPPVPIERNNQPFERRIPSPRPSLPMDKRFNPEEDAPKRQVPPPGGLGFSSNTFPPRPSAKNSFPGLPVTEGPSPPGPAPPPHKPGNMNRSFSEGTCNGRPPAPIPTSYNQTSATEKESLSQDQWYTGNISRSEAETALRSINQDGTFLVRNSSKSTASHPYVLMVLYRNKVYNIQIRQDQTNGLYMLGTGLRGQETFTSVEEIIDYFHKTPLLLIDGKDQSSRQHCMLTFAAGCCLT","proteome":null,"gene":"lcp2","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"190d09b0b4b86976c234bdfc01d2af40bb4cc996","counters":{"domain_architectures":657,"entries":16,"isoforms":0,"proteomes":0,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"pfam":2,"cdd":1,"smart":1,"profile":1,"panther":1,"prints":1,"interpro":5},"proteome":0,"taxonomy":1,"similar_proteins":657}}}