{"metadata":{"accession":"A0A7R5L893","id":"A0A7R5L893_9PASS","source_organism":{"taxId":"649802","scientificName":"Pipra filicauda","fullName":"Pipra filicauda (Wire-tailed manakin)"},"name":"PAS domain-containing serine/threonine-protein kinase","description":["Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation"],"length":1158,"sequence":"MAAKAFSASEGGLLPSSAGLVLTCLNDSDKLSRSYPWGDKRRKSRLSGLCRLRASLSGEKWSSYCLSSLTARNICSSKTGNSWAQWDSTSLSASIGSSASCSFLHAPAVEESSQHLPAAARNPNKAIFTVDAGTTEILVANDRACKLLGCSSQELIGQKLSHLISKPSQEVWEAVGEEYLETYEWSSVVSGTVMDVRGRLNEKIPVSVWQRQIRSKDTQRCVVVLEPVERLSASVCFRVDGEITSCDLLFAHLHGYPTLEEVVGLHIKDLIPSVQIPPLGKKIPKNLRTQRAAGRSREGNVFPLSLKLQASLLEEDQARVQKDGILQTEGSLPGYQYSATVVVFSTISGLITVQSDGIICGINDSFALMLFGYEKKELLGKNITFLIPGFYNNMERSSECSLPFPPLDDSTGTEERHICIKTNAPHWNKEEFLDGFLDSSSLAASLAHLLSRDEEQKWEQRRKDDKLIHDENKQKSGTGFFSPPSPPEVASTPTNSSRLEDILNTSSYGPVKLPSVVTSNSPGTPTMNEPWPGTALDCRQDFQSHVVTGQASKTNSRCDAEHSSLEQVVVENCLLNDAPAFFAHERNTVYDVCSANKVGHSASAPGAATTSEDVKESDTELNCICSGLEVLGLNTRVKGNSDNSLGVTAALVGACSSDAVDSNMLTETNSTFSAGQGKQLLSGVATEAGSGWLAFQGHLQNSEESSKAFPEAAQTPAETVGHSAGRNPQKGKGGPEELGQLQGQQNMERKVTSTPVKQEGRLNPAAPLIWEILEGSYTGNCCHRDGSQFSILFEVKCAELQDPTVLFCVWVVKDLSQSQKEAVAKTQPLLSSLASSAQSVADLSTNSLGEAIRSTSLFNNSRRAEELGGLRACEGEYTKNYSTLSLIGKGAFGFVWTARSKKDHQEVVVKFIWKERVLEDCWVDDPELGRVTQEIAILLKLQHPSIIKVLDVFENECFFQLVMEKHGSGLDLFTFIDNQPNLDEPLASYIFRQLVSAVGYLHCRNILHRDIKDENIVIAEDFTIKLVDFGSAAYLEPGKLFYTFCGTIEYCSPEVLSGKPYHGPELEMWSLGITLYTLVLGENPFCELEEALAAVLNPPHPVSDGLMDLMAGLLHPIPEERTTLAVLAEDPWLRQPVNLADYTWEEVYISAEPGETTS","proteome":"UP000504627","gene":"PASK","go_terms":[{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"131051ef29cc19e4e5d1718894fd55a365c023ff","counters":{"domain_architectures":245,"entries":24,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"ncbifam":1,"profile":2,"smart":2,"cathgene3d":3,"ssf":2,"pfam":3,"cdd":1,"panther":1,"prosite":2,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":245}}}