{"metadata":{"accession":"A0A7N9I9N4","id":"A0A7N9I9N4_MACFA","source_organism":{"taxId":"9541","scientificName":"Macaca fascicularis","fullName":"Macaca fascicularis (Crab-eating macaque)"},"name":"Aldose 1-epimerase","description":["Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose"],"length":334,"sequence":"MASVTRAAFGELPSGGGTVEKFQLQSDLLRVDIISWGCTITALEVKDRQGRASDVVLGFAELEGYLQKQPYFGAVIGRVANRIAKGTFKVDGKEYHLAINKEPNSLHGGVRGFDKVLWTPRVLSNGVQFSRISPDGEEGYPGELKVWVTYTLDGGELVVNYRAQASQATPVNLTNHSYFNLAGQGSPNIYDHEVTIEADTYLPVDETLIPIGEVAPVQGTAFDLRKPVELGKHLQDFHLNGFDHNFCLKGSKEKHFCARVHHAASGRVLEVYTTQPGVQFYTGNFLDGTLKGKNGAVYPKHSGFCLETQNWPDAVNQFCFQHGIIWRQRNLEDT","proteome":"UP000233100","gene":null,"go_terms":[{"identifier":"GO:0030246","name":"carbohydrate binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005975","name":"carbohydrate metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016853","name":"isomerase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019318","name":"hexose metabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"1389fa895f91fb3286328135ca905483790acfcc","counters":{"domain_architectures":40920,"entries":14,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":1,"pirsf":1,"panther":1,"pfam":1,"ncbifam":1,"prosite":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":40920}}}