{"metadata":{"accession":"A0A7N6B9T3","id":"A0A7N6B9T3_ANATE","source_organism":{"taxId":"64144","scientificName":"Anabas testudineus","fullName":"Anabas testudineus (Climbing perch)"},"name":"MAP/microtubule affinity-regulating kinase 3","description":["Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1"],"length":776,"sequence":"MSTRTPLPTVNERDTENHSSVDGFVEPPVPPTKSASRHSLPRCRNSFTSTEEHPHIGNYRLLKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQRRIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPVKRGSLEQIMKDHWMNVGHEEEELKPYIEPEADFSDTARIELMVTMGFPKDEITESLQGQKYDDVMATYLLLGRKAPEFEGNEPLTNSILGQRQRPTSDINNSSSISPAHPKVTRSISANQKQRRYSDHVGPSVPPAVSYTKRGQALSVESDHREEWDGARRLELSTSKGDVPASPLGVQERKKTTSATNGSMTRRNTYVCERSSTDRYSAIPNGKDSSLTEVSGSTPSTAISATRPRHTKSMSSSGHPSKSTLPPIDDNTELKGCFCSSPRGPSTSPSAHSISTPEKNRFPRGTTSRSTFHGAQLRDRRSATYNGPPASPTLSHDTGALTQQRRGTSTGIISKITSKFVRRVPSEGEASARTETPRRASSDTKEDSGRDSKPRSLRFTWSMKTTSSMEPAEMMREIRKVLDANSCDYEQRERFLLFCVHGDARQDNLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIACKIANELKL","proteome":"UP000265040","gene":"MARK1","go_terms":[{"identifier":"GO:0004674","name":"protein serine/threonine kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"41c929664501752aa367c8370f78a987cdcbbfe0","counters":{"domain_architectures":7295,"entries":27,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"ssf":2,"cdd":2,"profile":3,"pfam":3,"smart":2,"panther":1,"prosite":2,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":7295}}}