{"metadata":{"accession":"A0A7N5KF67","id":"A0A7N5KF67_AILME","source_organism":{"taxId":"9646","scientificName":"Ailuropoda melanoleuca","fullName":"Ailuropoda melanoleuca (Giant panda)"},"name":"FXYD domain-containing ion transport regulator","description":["Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. May increase NKA activity by increasing the apparent affinity for Na(+). Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis"],"length":246,"sequence":"MSPSGRLCLLTIIGLILPTRGQILKEATSTSPEDPARVNIHALTPAPDAGHLEPQSTPQTTLQTGGTTQEQEEETQSPQTEGTQSPQPTGMHGLLATGPRTGKSGAEATPSAEPTKGTTLSKRQSPGKGIRSDPVLRPTGSSEDDPFTYDEGTLRKRGLLVAAVLFITGIVILTSGKCRRLPQLCRNRNRAYRIVSKAHRAREDPDGARARADGPRPLPLSPHPPRGPPGLPGLCPPSYPFCSDEK","proteome":"UP000008912","gene":"FXYD5","go_terms":[{"identifier":"GO:0099106","name":"ion channel regulator activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0043269","name":"regulation of monoatomic ion transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a6b0f0c4b2168d3a7a214e17be666e81b4d7355c","counters":{"domain_architectures":4100,"entries":7,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"cdd":1,"panther":1,"pfam":1,"prosite":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":4100}}}