{"metadata":{"accession":"A0A7N4PQF6","id":"A0A7N4PQF6_SARHA","source_organism":{"taxId":"9305","scientificName":"Sarcophilus harrisii","fullName":"Sarcophilus harrisii (Tasmanian devil)"},"name":"Thromboxane-A synthase","description":["Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE"],"length":508,"sequence":"MGFLTSLSMETWTLLVLCGTLLILYGIWPYSFFKKLGIPGPRPLPFVGTFLEYRKGILEFDKNCFKKYGKMWGFYDGRQPILAILDPALIKIVLVKEFYTLFTNRRTFGLNGNLKSAITIAEGEKWKWLRATISPTFTSGKLKEMFPLIKNHVIVLLKNIEKRLAKDESMNMKGIFGAYSLDVITSTSFGVDIDSINNPNDPFLVRIKKLLSFGFLNPLLILILVFPSVVPILEKMNVTLFSKKILDFLVNSMRRIMVDRQKSNSRDRMDFLQLMIDSQATNDPESKENNSPKALTEMEIAAQAVTFLFAGYETTSTTLGFIAYNLATHPEIQKKLHEEIDRTLPNKAALTYDIIFQMEYLDMVVNETLRLFPLGGRIERICGKTAEINGLTIPKGTIMMIPVYVLHHDPEYWPEPEEFRPERFDREGRKSIDPYIFLPFGAGPRNCIGMRFALLTMKTALVMLLQNFTLEPCKETPIPLELDTKGFMQPKKPIILKLVPRTKLHAEE","proteome":"UP000007648","gene":"LOC100930770","go_terms":[{"identifier":"GO:0004497","name":"monooxygenase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005506","name":"iron ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016705","name":"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0020037","name":"heme binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a02e61ba6c64bb9a9c779746e03a6c43264a16fb","counters":{"domain_architectures":520850,"entries":12,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"panther":1,"prosite":1,"prints":2,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":520850}}}