{"metadata":{"accession":"A0A7N4P5D7","id":"A0A7N4P5D7_SARHA","source_organism":{"taxId":"9305","scientificName":"Sarcophilus harrisii","fullName":"Sarcophilus harrisii (Tasmanian devil)"},"name":"Rho GTPase-activating protein 10","description":["GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes. Also converts Cdc42 to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death. Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins"],"length":785,"sequence":"MGLQPLEFSDCYLDSPWFRERIRAHEAELEKTNKFIKELLKDGKNLIAATKNLSLAQRKFAHSLRDFKFEFIGDAETDDERCIDASLREFSNFLRNLEEQREIMALSVTETLIKPLEKFRKEKLGAVKEEKKKFDKETEKNYSLLDKHLNLSAKKKDAHLQEADIQVEQNRKHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQKTRNRFEGTRSEVEDLMNKIRQNPKEHKRASQFAVEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKFTMIPFEHRSGGKIGDGDVFSLKECTKRHTDSIDRRFCFDVEAADRPGIPMTMQAFSEEERKQWMEALGGKEALLPSLNRANLRREGGAQLDKIGFTILRKCIRAVETRGINDQGLYRVVGVSSKVQRLLSVLMDAKTCNEVDLENSLDWEVKTITSALKQYLRSLPEPLMTYDLHGEFIIPAKSGSPESRVNAIHFLVHRLPEKNKEMLDILVKHLTNVSNHAKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIENHEKIFRTVPDATLPEPISMSTSPPNAPPRQSKRQGQRNKRPVAVYNLCLELEDADNPSPPKEDTPTGSLDSLSSHSPTPATLSSSPGPEKNHLLTDGGELADWASNHPSQARPPMVQWLNPQSPSSLSAHPAAAPSSPVSSSFCFSSPAVMADKPAESVVSRKARAVYPCEAEHSSELSFEIGAVFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL","proteome":"UP000007648","gene":"ARHGAP10","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005737","name":"cytoplasm","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005096","name":"GTPase activator activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4b65fd57722a4c9517b19c3bc83016a3a4f3979d","counters":{"domain_architectures":3698,"entries":33,"isoforms":0,"proteomes":1,"sets":7,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"ssf":4,"pfam":4,"profile":3,"smart":3,"cdd":3,"panther":1,"interpro":11},"proteome":1,"taxonomy":1,"similar_proteins":3698}}}