{"metadata":{"accession":"A0A7N4NVN5","id":"A0A7N4NVN5_SARHA","source_organism":{"taxId":"9305","scientificName":"Sarcophilus harrisii","fullName":"Sarcophilus harrisii (Tasmanian devil)"},"name":"Uracil-DNA glycosylase-like domain-containing protein","description":["Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration"],"length":273,"sequence":"MAKLLASPMGSLEESLPGLQKFPCCLSNIAQDFLEEELRLNAELDKLQFSEPVGFIYNPLKYALELHQNYVTKYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVSVVRDWLGIVGTVLTPPEEHPKRRILGLQCPQSEVSGARFWGFFRALCGQPETFFRHCFVHNLCPLLFLAPSGRNLTPADLPAKQREQLLGACDTALRRQVQLLGVRLVVGVGRLAEQRARRALADIVPEVQVEGLLHPSPRSPQANRGWEAVARERLKELGLMPLLTVE","proteome":"UP000007648","gene":"SMUG1","go_terms":[{"identifier":"GO:0017065","name":"single-strand selective uracil DNA N-glycosylase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006284","name":"base-excision repair","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"6d3eb109c1e174cd82c598bd72ab8f3ce4283767","counters":{"domain_architectures":69726,"entries":8,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":1,"pfam":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":69726}}}