{"metadata":{"accession":"A0A7M7N4U6","id":"A0A7M7N4U6_STRPU","source_organism":{"taxId":"7668","scientificName":"Strongylocentrotus purpuratus","fullName":"Strongylocentrotus purpuratus (Purple sea urchin)"},"name":"DNA-directed RNA polymerase III subunit RPC9","description":["Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues","DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway"],"length":141,"sequence":"MEVVKESAAMLSNYEVHALLKELQAGALREGRRASAKKKQNLATISYETIKYLENTPCGLQTPEVVEKFLQALAPFNLTKSEKLQLLNHRPTTSVEIMAMVEECEERLSEDQMESLIKVITSMLPGEQEEEGAEGEEGEEG","proteome":"UP000007110","gene":null,"go_terms":[{"identifier":"GO:0000166","name":"nucleotide binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006384","name":"transcription initiation at RNA polymerase III promoter","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005666","name":"RNA polymerase III complex","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0006352","name":"DNA-templated transcription initiation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0030880","name":"RNA polymerase complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"00ff8f23a337786e25d53a90c9e5a62021b5c458","counters":{"domain_architectures":9806,"entries":10,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"smart":1,"ssf":1,"panther":1,"pfam":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":9806}}}