{"metadata":{"accession":"A0A7M7GVP7","id":"A0A7M7GVP7_APIME","source_organism":{"taxId":"7460","scientificName":"Apis mellifera","fullName":"Apis mellifera (Honeybee)"},"name":"Cytoplasmic tRNA 2-thiolation protein 1","description":["Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position"],"length":343,"sequence":"MPIPCSRKCGKDAILKRPKTGHALCKECFFFAFESEIHNTIVQGKLFKSGDKVAIGASGGKDSTVLAYVLKTLNNKYQYGIDLFLLSIDEGITGYRDDSLKTVQQNKNDYGLPLKILSYKELYGWTMDEIVAEIGKKNNCTFCGVFRRQALDRGAALLGVDCIATGHNADDIAETVLMNILRGDIARLQRCTSVITAGADCIRRCKPLKYAYEKEIVMYAYFKQLVYFSTECIFAPNAYRGHARTFLKDLEKVRPSSILDIIHSGETLQIKENIKLPERRNCSRCGFVSSQEICKACIMLEGLNRGLPKLGIGKSTKVKKVIDSVANNKSENNDKIKLKSLEF","proteome":"UP000005203","gene":"413889","go_terms":[{"identifier":"GO:0000049","name":"tRNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0002098","name":"tRNA wobble uridine modification","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0034227","name":"tRNA thio-modification","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008033","name":"tRNA processing","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"868d66e0b8b944de72d0f146f7281e2b33a283c8","counters":{"domain_architectures":148,"entries":19,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"pfam":3,"cdd":1,"ssf":1,"hamap":1,"panther":1,"pirsf":1,"ncbifam":1,"prosite":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":148}}}