{"metadata":{"accession":"A0A7L4EZG7","id":"A0A7L4EZG7_HIRRU","source_organism":{"taxId":"43150","scientificName":"Hirundo rustica","fullName":"Hirundo rustica (Barn swallow)"},"name":"Thioredoxin-interacting protein","description":["May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1)"],"length":390,"sequence":"MVMFKKVKSFTVAFSEPDKIYCSGDKVAGRVLVEVAEVTRVSAVKVLACGVARVTWAKGPAQCRQEMEYLRFEDVLALEEQPTDDDGSVILRPGNKYEYKFGFELPQGPLGTTFKGKYGSVDYWVKASLERPACPTQQVKKRFEVMDPVDVNTPELLSPVAAKKEEKVSCMFIPDGRVSVSAQIDRKGFCEGDEICINADFENTCSRIVVPKAAIVAKHTYLANGQTKVFCQKLSCVRGNHIISGTSESWRGKTIRVRKLKPSILGCNILRVEYFLQIYVSVPGSKKIILELPLVIGSRSGIGSRSSSMASQTSSEMSWVDLNLPDAPEAPPCYLDIVPEDHRLESPTTPLLDDPDGFDSPIFMYAPEFKFMPPPTYTEVDPCVANNNIQ","proteome":null,"gene":"Txnip","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"59e7dc3418e2699290ec55cb5102b7cea0ac7128","counters":{"domain_architectures":23199,"entries":11,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":2,"smart":1,"panther":1,"interpro":5},"proteome":0,"taxonomy":1,"similar_proteins":23199}}}