{"metadata":{"accession":"A0A7K7M2H2","id":"A0A7K7M2H2_9PASS","source_organism":{"taxId":"3235156","scientificName":"Brachypodius melanocephalos","fullName":"Brachypodius melanocephalos (black-headed bulbul)"},"name":"Acyl-coenzyme A thioesterase 8","description":["Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT). Is also able to hydrolyze CoA esters of dicarboxylic acids. It is involved in the metabolic regulation of peroxisome proliferation"],"length":301,"sequence":"GDLRSVLITSVLNLERLEVDLFRCAGRHHWVPATQHLFGGQIVGQALVAAAHAVSRDEQVHSLHCYFVRTGDPKVPVLYEVERTRTGKSFSVRSVKAIQHGKPIFTCQASFQLSQGSPVQHQFTMPTVPPPEELLTQDELIQKFLQNPNVAEGYRKRLTKIQAQDVPIDIKPVNPPDIFSLEPQEPKQLFWVRARGYIGETDMKVHCCVAAYISDYAFLGTALLPHRQYRIKFMVSLDHSMWFHAPFRADHWMLYECESPWAGGCRGLVQGRLWRRDGVLAVTCAQEGVIRVEQTPNQSKL","proteome":"UP000540762","gene":"Acot8","go_terms":[{"identifier":"GO:0047617","name":"fatty acyl-CoA hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006637","name":"acyl-CoA metabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"fd1a9168905e51b62daba36d9e70782041295dfb","counters":{"domain_architectures":13240,"entries":13,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":2,"pfam":2,"panther":1,"ncbifam":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":13240}}}