{"metadata":{"accession":"A0A7K5BPB3","id":"A0A7K5BPB3_MOTAL","source_organism":{"taxId":"45807","scientificName":"Motacilla alba","fullName":"Motacilla alba (White wagtail)"},"name":"TGF-beta-activated kinase 1 and MAP3K7-binding protein 2","description":["Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development"],"length":698,"sequence":"MAQGSQQIDIQVLHDLRQKFPEVPEGVVSRCMLQNNNNLDACCAVLSQESTKYLYGEGDLSFSDDSGIPGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLAHSVSDGHLQTSQSNNELFQQEPQTAPAQVPQGFNVFGMANTVSASNPGQHLGFHLGSKGVSNLSQQTPRFNPIMVTLAPNIQPGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITAPSGTARQTQQQPGWASQFNPMHPQQVYQPSQPGPWTTIPTSSTTPHTSSQHSTQPNQQGHQTSHVYMPISSPTTPQAPMIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNSSSKLRSTGPRTSTVPSSLNSQTLSRSQPTVYISASPPNTDEVITRGQPKVYISANATTGDDQLVRNQPTLFISTNPGVSTTARNMSGQVSMGPAFIHHHPPKSRAVGNSTTATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFEPTNLLNLPDHYVEPEGIQHLTDPVLAHVDRISDARKLSMGSDDAAYTQALLVHQKARMERLQRELEVQKKKLDKLKSEVNEMENNLTRRRLKRSNSVSQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFLGPVPPKPKDQRSIVKTPKTVPDTDEDEGAQWSCTACTFLNHPALNRCEQCEMPRHF","proteome":"UP000532252","gene":"Tab2","go_terms":[{"identifier":"GO:0043130","name":"ubiquitin binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"6a1420a2d828932f2dc809150049cfa63156530f","counters":{"domain_architectures":15330,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"smart":2,"profile":2,"cdd":1,"pfam":1,"ssf":1,"panther":1,"prosite":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":15330}}}