{"metadata":{"accession":"A0A7K4PCB4","id":"A0A7K4PCB4_MELMO","source_organism":{"taxId":"44397","scientificName":"Melospiza melodia","fullName":"Melospiza melodia (Song sparrow)"},"name":"Nociceptin receptor","description":["G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin"],"length":368,"sequence":"MDPLFPARIFEDPDLRKLLNDSSMLNLSFLPSNWFNNSTGDGFLPLSIKITIVVVYSIVCIVGLVGNCSVMYVIVRFTKMKTATNIYIFNLALADTLCLMTLPFQGTDTFLGFWPFGNVLCKIAISIDYYNMFTSTFTLTMMSVDRYIAICHPIKALDIRTPHKAKVVNVCIWALASVFGIPAMVMGSAENENNEIDCLIKLPSPVDYWDPVFGICVFLFSFMIPVLIITICYSLMIRRLKNVRVLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIQIFVLVQCLGAKAESELELAISCFCTALGYANSSLNPVLYAFLDENFKACFKKFCFPTAFRTELQMSNRMCSIAKDVAYACKNSEGTNNPA","proteome":"UP000560247","gene":"Oprl1","go_terms":[{"identifier":"GO:0004930","name":"G protein-coupled receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0001626","name":"nociceptin receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004985","name":"G protein-coupled opioid receptor activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"587fa3dbe4504dc051049f3cca904dd9ab631b87","counters":{"domain_architectures":394800,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"cdd":1,"smart":1,"profile":1,"pfam":1,"panther":1,"prosite":1,"prints":3,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":394800}}}