{"metadata":{"accession":"A0A7J8EVV1","id":"A0A7J8EVV1_MOLMO","source_organism":{"taxId":"27622","scientificName":"Molossus molossus","fullName":"Molossus molossus (Pallas' mastiff bat)"},"name":"Wee1-like protein kinase","description":["Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation"],"length":646,"sequence":"MSFLSRQQPPPPRRSGASCTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDSPLPPARSPPEPGPEGRRSPSPAPGSPGELEEDMLLRGASPGADASGGGAEGDSWEEEGFGSSSPVKSPAAAYFLGSSFSPVRCGGPEDASPRGYGERRAGEGPCSPLRDHPGTPPHKTFRKLRLFDTPHTPKSLLSKARGIDSSSVKLRGGSLFMDTEKSGKREFDIRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYEFEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISINYRSMSYFIEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEDGDEDDWVSNKVIFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYSHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFMELLKVMIHPDPERRPSATALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY","proteome":"UP000550707","gene":"HJG59_019556","go_terms":[{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0000287","name":"magnesium ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004715","name":"non-membrane spanning protein tyrosine kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0000278","name":"mitotic cell cycle","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"726173b0dde7bbc50c5d845a39c992d18faf18f3","counters":{"domain_architectures":887312,"entries":17,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":2,"cdd":1,"pfam":1,"smart":1,"profile":1,"pirsf":1,"panther":1,"prosite":2,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":887312}}}