{"metadata":{"accession":"A0A7J8APN4","id":"A0A7J8APN4_MYOMY","source_organism":{"taxId":"51298","scientificName":"Myotis myotis","fullName":"Myotis myotis (Greater mouse-eared bat)"},"name":"DNA repair protein RAD51 homolog","description":["Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair","Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair"],"length":339,"sequence":"MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILTEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARGFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD","proteome":"UP000527355","gene":"mMyoMyo1_016227","go_terms":[{"identifier":"GO:0000166","name":"nucleotide binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0140664","name":"ATP-dependent DNA damage sensor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006281","name":"DNA repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008094","name":"ATP-dependent activity, acting on DNA","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006259","name":"DNA metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0000150","name":"DNA strand exchange activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003690","name":"double-stranded DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003697","name":"single-stranded DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0000724","name":"double-strand break repair via homologous recombination","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:1990426","name":"mitotic recombination-dependent replication fork processing","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"c8df90c6b2b58269ecf5a106897e30287760edef","counters":{"domain_architectures":5114,"entries":23,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"pfam":2,"profile":2,"cdd":1,"smart":1,"pirsf":1,"panther":1,"ncbifam":2,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":5114}}}