{"metadata":{"accession":"A0A7J7ZPE3","id":"A0A7J7ZPE3_PIPKU","source_organism":{"taxId":"59472","scientificName":"Pipistrellus kuhlii","fullName":"Pipistrellus kuhlii (Kuhl's pipistrelle)"},"name":"Bax inhibitor 1","description":["Endoplasmic reticulum (ER)-resident protein that confers cellular protection as an anti-apoptotic protein by limiting multiple stress-inducing pathways surrounding the endoplasmic reticulum and mitochondria. Inhibits the activities of the key sensor for the endoplasmic reticulum unfolded protein response IRE1alpha/ERN1 both directly and by blocking BAX/BAK binding. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation"],"length":237,"sequence":"MNIFDRKINFDALLKFSHISPSTQQHLKKVYASFALCMFVAAAGAYVHVVTHFVQAGLLSALGSLGLMIWLMTTPHSHETEQKRLGLLAGFAFLTGVGLGPALEFCIAINPSIIPTAFMGTAMIFTCFTLSALYARRRSYLFLGGILMSAMSLMLLSSLGNLFFGSIWLFQANLYLGLMVMCGFVLFDTQLIIEKAENGDKDYIWHCVDLFLDFVTLFRKLMMILAMNEKDKKKEKK","proteome":"UP000558488","gene":"mPipKuh1_017496","go_terms":[{"identifier":"GO:0043066","name":"negative regulation of apoptotic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"82455095b0854e5bcd1644042a3a2dd6ee243050","counters":{"domain_architectures":36348,"entries":6,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"pfam":1,"panther":1,"prosite":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":36348}}}