{"metadata":{"accession":"A0A7E6CT36","id":"A0A7E6CT36_9CHIR","source_organism":{"taxId":"89673","scientificName":"Phyllostomus discolor","fullName":"Phyllostomus discolor (pale spear-nosed bat)"},"name":"Protein strawberry notch homolog 1","description":["Plays a crucial role in the regulation of neural stem cells (NSCs) proliferation. Enhances the phosphorylation of GSK3B through the PI3K-Akt signaling pathway, thereby upregulating the Wnt/beta-catenin signaling pathway and promoting the proliferation of NSCs. Improves ischemic stroke recovery while inhibiting neuroinflammation through small extracellular vesicles (sEVs)-mediated mechanism. Enhances the secretion of sEVs from NSCs, which in turn inhibit both the MAPK and NF-kappaB pathways in microglia. This inhibition suppresses the pro-inflammatory M1 polarization of microglia, promoting a shift towards the M2 anti-inflammatory phenotype, which is beneficial for reducing neuroinflammation"],"length":1357,"sequence":"MVEPGQDLLLAALSESGISPNDLFDIDGGDAGLATPTPPPPVHQQPPSTTTFVLNQINQLPTLGSTIVMTKTPPVTTSRQTITLTKFIQTTANTRPSVSAPAARNAVTPAPPKDQVQLKDLLKNNSLNELMKLKPPANIAQPVATAATDVSNGTIKKESSNKEVARIWINDMKMRSFSPTMKVPVVKEEEEPEEEDEEEMGHAETYAEYMPIKLKIGLRHPDAVVETSSLSSVTPPDVWYKTSISEETIDNGWLSALQLEAITYAAQQHETFLPNGDRAGFLIGDGAGVGKGRTIAGIIYENYLLSRKRALWFSVSNDLKYDAERDLRDIGAKNILVHSLNKFKYGKISSKHNGSVKKGVIFATYSSLIGESQSGGKYKTRLKQLLHWCGDDFDGVIVFDECHKAKNLCPVGSSKPTKTGLAVLELQNKLPKARVVYASATGASEPRNMAYMNRLGIWGEGTPFREFSDFIQAVERRGVGAMEIVAMDMKLRGMYIARQLSFTGVTFKIEEVLLSQSYVKMYNKAVKLWVVARERFQQAADLIDAEQRMKKSMWGQFWSAHQRFFKYLCIASKVKRVVQLAREEIKNGKCVVIGLQSTGEARTLEALEEGGGELNDFVSTAKGVLQSLIEKHFPAPDRKKLYSLLGIDLTAPSNSSSPRDSPCKEKKIKKRKGEETPREAKKARRAGGLTGSSSDDSASESDASDREESDYESSKNMSSGDDDDFNPFRDESSEDDEDDPWLIRKDHKKNKDKKRKKSIDPDSIQSALLASGLGSKRPSFSSTPVISPAPNSAPANSNTNSNNSLVTSQDAVERAQQMKKDLLDKLEKLAEDLPPNTLDELIDELGGPENVAEMTGRKGRVVSNDDGSISYESRSELDVPVEILNITEKQRFMDGDKNIAIISEAASSGISLQADRRAKNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVTAPEYVFLISELAGEQRFASIVAKRLESLGALTHGDRRATESRDLSRFNFDNKYGRNALEIVMKSIVNLDSPMVSPPPDYPGEFFKDVRQGLIGVGLINVEDRSGILTLDKDYNNIGKFLNRILGMEVHQQNALFQYFADTLTAVVQNAKKNGRYDMGILDLGSGDEKVRKSDVKKFLTPGYSTSGHVELYTISVERGMSWEEATRIWAELTGPDDGFYLSLQIRNNKKTAILVKEVNPKKKLFLVYRPNTGKQLKLEIYADLKKKYKKVVSDDALVHWLDQYNSSADTCTHAYWRGNCKKASLGLVCEIGLRCRTYYVLCGSVLSVWTKVEGVLASVSGTNVKMQIVRLRTEDGQRIVGLIIPANCVAPLVNLLSTSDQSQQLAVQQKQLWQQRHPQSIASLSST","proteome":"UP000504628","gene":"SBNO1","go_terms":[{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"8c09c40994542d16378810f1e37de59f493a8fd4","counters":{"domain_architectures":3582,"entries":11,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"pfam":3,"cathgene3d":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":3582}}}