{"metadata":{"accession":"A0A7E6CM46","id":"A0A7E6CM46_9CHIR","source_organism":{"taxId":"89673","scientificName":"Phyllostomus discolor","fullName":"Phyllostomus discolor (pale spear-nosed bat)"},"name":"Histone-lysine N-methyltransferase SETDB2","description":["Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis"],"length":572,"sequence":"MKMPLTFKGENPLQLPISCHFQRRHAKTNTHSSALHVSYKTPCGRSLRNMEEVFRYLLETECNFLFTDNFSFNTYVQLTRNYPKQEEIVSDLDISNGVELVPISFCNEIDNRKLPHFKYRKTIWPRAYYLSSFPNIFTDSCDCSEGCIDITKCACLQMTARNAEICPLSRDKITIGYKYKRLQRHIPTGIYECSLLCKCNRQMCQNRVVQHGPQVRLQVFKTEKKGWGVRCLDDIDRGTFVCTYSGRLLSRSNTGKPDAIGENRKEENIMKNVFSKRRKIEVADCEVEVIPLELDRNAKTEECPAKFSNNQKKPVTDMKCNNISRIRYHSAIRTLKTKIAIIQPDGRKMGFASSESVTSEGNDGFKPTQIHLTTKANDMKNRLLVNASSNQVEDSEDKLLIESDVIDITKCKEETSLRGRYSKATTMDNQNIMKEFEAQILKPQEKRFPACQNQQVVCGKELSSETKNTSSDQMNTSSDSLKFNKGDVFLLDATKEGNVGRFLNHSCYPNLLVQNVFVETHDRNFPLVAFFTNRYVKARTELTWDYGYEAGTVPDKEILCQCGVNKCRKKIL","proteome":"UP000504628","gene":"SETDB2","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0042054","name":"histone methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e8852bd35141b2632ca4136583a2448e02a9845f","counters":{"domain_architectures":993,"entries":22,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"profile":3,"pfam":3,"ssf":2,"smart":3,"cdd":1,"cathgene3d":2,"panther":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":993}}}